GLP-1/GIP + B12 is a dual agonist of the GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors. It was originally developed to treat type 2 diabetes by regulating blood sugar and promoting weight loss. By mimicking the effects of these natural hormones, GLP-1/GIP + B12 stimulates insulin production, decreases glucagon secretion, and helps manage appetite. These effects contribute to improved metabolic health and reduced inflammation. Recently, GLP-1/GIP + B12 has gained attention for its potential in supporting long-term health and longevity.

Microdosing GLP-1/GIP + B12 involves taking lower doses of the medication, focusing on longevity rather than just blood sugar regulation or weight management. As a dual GIP/GLP-1 receptor agonist, GLP-1/GIP + B12 can help reduce inflammation, improve metabolic function, and enhance cardiovascular health—key factors for maintaining vitality as we age. While it is not intended for significant weight loss, microdosing GLP-1/GIP + B12 may reduce appetite and cravings, leading to gradual, sustained weight management. The primary focus, however, is on supporting metabolic health and longevity. 

Please be advised that microdosing GLP-1/GIP + B12 for off-label use as a longevity product does not have a BMI requirement at this time. This differs from our weight management product, which requires a BMI of 28 or higher.

Before starting any treatment, including the off-label use of GLP-1/GIP + B12, it is critical to consult with a qualified healthcare provider. 

GLP-1/GIP + B12 is associated with certain contraindications, which include, but are not limited to: 

• Personal or Family History of Medullary Thyroid Carcinoma (MTC): GLP-1/GIP + B12 may increase the risk of thyroid tumors in individuals with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
• Hypersensitivity: GLP-1/GIP + B12 is contraindicated in patients with known hypersensitivity to the drug or its components, as it may cause allergic reactions like anaphylaxis.
• Pregnancy: GLP-1/GIP + B12 is not recommended during pregnancy, and should be discontinued at least two months before a planned pregnancy.
• Diabetic Ketoacidosis (DKA): GLP-1/GIP + B12 is not indicated for type 1 diabetes or DKA. 

Microdosing GLP-1/GIP + B12 is an off-label longevity product and not a dedicated weight management solution. For significant weight loss, we recommend our weight management product. However, microdosing GLP-1/GIP + B12 can still help reduce appetite, curb cravings, and promote gradual, sustained weight loss for those looking to maintain a healthy weight. 

Individuals who are interested in seeking the following may benefit from microdosing GLP-1/GIP + B12: 

• Metabolic Health: Individuals with insulin resistance or prediabetes may benefit from GLP-1/GIP + B12’s ability to stabilize glucose and improve insulin sensitivity.
• Sustained Weight Loss: While not intended for major weight loss, microdosing may assist in appetite control, promoting gradual, sustained weight loss.
• Cardiovascular Health: GLP-1/GIP + B12 may reduce cardiovascular risk by improving cholesterol levels, lowering blood pressure, and reducing inflammation.
• Preventative Health: For those focused on longevity and preventative aging, GLP-1/GIP + B12 can be a valuable tool in maintaining metabolic health and reducing chronic disease risk.
• Neuroprotection: Early evidence suggests that GLP-1/GIP + B12 may have neuroprotective benefits, making it an attractive option for those looking to protect cognitive function as they age.

The recommended off-label longevity protocol for microdosing GLP-1/GIP + B12? is 2.5mg per week.

You will receive a vial containing 30mg of GLP-1/GIP + B12 (vial size and concentration may vary by pharmacy). At the recommended dose of 2.5mg per week, this should last a minimum of 12 weeks.

Yes! Your prescription will come with alcohol wipes, syringes, and all necessary items to get started.

Yes, it’s important to inform your primary care provider about any new treatments. While a medical professional will review your profile to determine eligibility, your primary care doctor can provide additional insights into your overall health and help ensure the best care. 

When comparing the potential longevity benefits of microdosing GLP-1 + B12 and GLP-1/GIP + B12, both medications offer overlapping health improvements due to their action on GLP-1 receptors. However, GLP-1/GIP + B12 also activates GIP (glucose-dependent insulinotropic polypeptide) receptors, which may offer additional advantages. 

Here's a breakdown of how these two medications compare in terms of longevity-related benefits:

• Metabolic Health: Both GLP-1 + B12 and GLP-1/GIP + B12 improve insulin sensitivity, stabilize blood sugar levels, and reduce the risk of developing type 2 diabetes. These actions help protect against metabolic disorders, which are linked to aging-related diseases like cardiovascular conditions, obesity, and neurodegeneration.
• Cardiovascular Health: Both drugs are effective in reducing risk factors for cardiovascular disease, such as lowering blood pressure, improving cholesterol levels, and aiding in weight management. Cardiovascular health is a key component of longevity, and reducing risks of heart attacks and strokes is crucial for a longer, healthier life.
• Inflammation Reduction: Chronic low-grade inflammation contributes to aging and is a major risk factor for diseases like Alzheimer’s, diabetes, and cardiovascular disease. Both medications exhibit anti-inflammatory effects, which are important in reducing the systemic inflammation linked to accelerated aging.
• Weight Management: GLP-1 + B12 and GLP-1/GIP + B12 both promote satiety and reduce appetite, leading to gradual and sustained weight loss. Maintaining a healthy weight is crucial for reducing the risks of many age-related diseases, including diabetes, heart disease, and some cancers.
• Neuroprotective Potential: GLP-1 receptor agonists, including both GLP-1 + B12 and GLP-1/GIP + B12, show early promise in providing neuroprotective benefits, potentially lowering the risks of neurodegenerative diseases like Alzheimer’s by reducing oxidative stress and inflammation in the brain.

Unique Potential Benefits of GLP-1/GIP + B12:

• Dual GIP/GLP-1 Receptor Agonism: GLP-1/GIP + B12’s unique mechanism of action as a dual agonist (GIP and GLP-1) may offer additional benefits over GLP-1 + B12. GIP may improve fat metabolism, reduce adiposity (fat accumulation), and provide a stronger impact on insulin sensitivity and glucose regulation. These effects could offer a more comprehensive approach to metabolic health, which is key to longevity.
• Enhanced Weight Loss: Clinical trials have shown that GLP-1/GIP + B12 can induce more significant weight loss compared to GLP-1 + B12. Since excess weight is a major risk factor for many chronic conditions, GLP-1/GIP + B12’s superior ability to promote weight reduction may enhance longevity more effectively in those who are overweight or obese.
• Greater Impact on Glucose Control: GLP-1/GIP + B12 appears to have a more pronounced effect on improving glucose control compared to GLP-1 + B12, which could make it a more powerful tool for preventing insulin resistance and type 2 diabetes—both significant factors in age-related health decline.

Key Considerations for Longevity:

• GLP-1 + B12 is well-studied for its effects on metabolic health, weight management, cardiovascular health, and inflammation reduction. It offers a strong foundation for longevity, especially for those primarily looking to stabilize metabolic function and improve cardiovascular health.
• GLP-1/GIP + B12, with its dual action on both GIP and GLP-1 receptors, may provide additional advantages in fat metabolism, insulin sensitivity, and weight loss. These factors make it potentially more effective for people who have more pronounced metabolic concerns or are at higher risk for obesity-related diseases.